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Theranostics 2018; 8(7):2061-2063. doi:10.7150/thno.24454 This issue Cite

Editorial

Resistant to Targeted Therapy - Aim for Metabolic Liabilities

André Lima Queiroz, Helin Vakifahmetoglu-Norberg, Erik Norberg✉

Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, SE-171 77, Stockholm, Sweden

✉ Corresponding author: Erik Norberg, Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, SE-171 77, Stockholm, Sweden. E-mail: Erik.Norbergse

Citation:
Queiroz AL, Vakifahmetoglu-Norberg H, Norberg E. Resistant to Targeted Therapy - Aim for Metabolic Liabilities. Theranostics 2018; 8(7):2061-2063. doi:10.7150/thno.24454. https://www.thno.org/v08p2061.htm
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Commentary-article in Theranostics, Volume 8, 1808

Abstract

The advent of targeted therapies generated much optimism when discovered. Targeted therapies, are however associated with rapid acquisition of resistance. In a recent study by Dong et al. (Theranostics 2018; 8(7):1808-1823. doi:10.7150/thno.23177) it was shown that lung tumors resistant to the EGFR-inhibitor (Erlotinib), reprogram their metabolism and acquire a pro-survival dependency on Phosphoglycerate Dehydrogenase (PHGDH) that can be targeted to eliminate resistant tumors.

Keywords: EGFR, Lung Cancer, Non-small Cell Lung Carcinomas, Lung Adenocarcinomas, PHGDH, Tumor Metabolism, Serine

Citation styles

APA
Queiroz, A.L., Vakifahmetoglu-Norberg, H., Norberg, E. (2018). Resistant to Targeted Therapy - Aim for Metabolic Liabilities. Theranostics, 8(7), 2061-2063. https://doi.org/10.7150/thno.24454.

ACS
Queiroz, A.L.; Vakifahmetoglu-Norberg, H.; Norberg, E. Resistant to Targeted Therapy - Aim for Metabolic Liabilities. Theranostics 2018, 8 (7), 2061-2063. DOI: 10.7150/thno.24454.

NLM
Queiroz AL, Vakifahmetoglu-Norberg H, Norberg E. Resistant to Targeted Therapy - Aim for Metabolic Liabilities. Theranostics 2018; 8(7):2061-2063. doi:10.7150/thno.24454. https://www.thno.org/v08p2061.htm

CSE
Queiroz AL, Vakifahmetoglu-Norberg H, Norberg E. 2018. Resistant to Targeted Therapy - Aim for Metabolic Liabilities. Theranostics. 8(7):2061-2063.

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