Theranostics 2017; 7(10):2575-2592. doi:10.7150/thno.20118

Review

Preparation and Application of Cell Membrane-Camouflaged Nanoparticles for Cancer Therapy

Yihui Zhai1, 2, Jinghan Su1, 2, Wei Ran1, 2, Pengcheng Zhang1✉, Qi Yin1, Zhiwen Zhang1, Haijun Yu1, Yaping Li1✉

1. State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China.

Abstract

Cancer is one of the leading causes of death worldwide. Many treatments have been developed so far, although effective, suffer from severe side effects due to low selectivity. Nanoparticles can improve the therapeutic index of their delivered drugs by specifically transporting them to tumors. However, their exogenous nature usually leads to fast clearance by mononuclear phagocytic system. Recently, cell membrane-camouflaged nanoparticles have been investigated for cancer therapy, taking advantages of excellent biocompatibility and versatile functionality of cell membranes. In this review, we summarized source materials and procedures that have been used for constructing and characterizing biomimetic nanoparticles with a focus on their application in cancer therapy.

Keywords: Cell membrane, Nanoparticle, Camouflage, Cancer.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Zhai Y, Su J, Ran W, Zhang P, Yin Q, Zhang Z, Yu H, Li Y. Preparation and Application of Cell Membrane-Camouflaged Nanoparticles for Cancer Therapy. Theranostics 2017; 7(10):2575-2592. doi:10.7150/thno.20118. Available from http://www.thno.org/v07p2575.htm