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Theranostics 2017; 7(6):1531-1542. doi:10.7150/thno.17247 This issue Cite

Research Paper

A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy

Juan Mou, Tianquan Lin, Fuqiang Huang, Jianlin Shi, Hangrong Chen✉

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China.

✉ Corresponding author: hrchensic.ac.cn

Citation:
Mou J, Lin T, Huang F, Shi J, Chen H. A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy. Theranostics 2017; 7(6):1531-1542. doi:10.7150/thno.17247. https://www.thno.org/v07p1531.htm
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Abstract

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A new kind of green titania (G-TiO2-x) with obvious green color was facilely synthesized from black titania (B-TiO2-x) through subsequently strong ultrasonication. Comparatively, this stable G-TiO2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth. Furthermore, since mitochondria are preferred subcellular organelles for PDT/PTT, G-TiO2-x was further designed to conjugate with triphenylphosphonium (TPP) ligand for mitochondria-targeted PDT/PTT to obtain precise cancer treatment. Attributing to the high mitochondria-targeting efficiency and simultaneously synergistic PDT/PTT, high phototherapeutic efficacy and safety with a much lower laser power density (980 nm, 0.72 W cm-2) and low materials dosage were achieved both in vitro and in vivo. In addition, negligible toxicity was found, indicating high biocompatibility. This novel G-TiO2-x could provide new strategies for future precise minimal/non-invasive tumor treatment.

Keywords: green titania, NIR absorption, mitochondria, photodynamic therapy, photothermal therapy.

Citation styles

APA
Mou, J., Lin, T., Huang, F., Shi, J., Chen, H. (2017). A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy. Theranostics, 7(6), 1531-1542. https://doi.org/10.7150/thno.17247.

ACS
Mou, J.; Lin, T.; Huang, F.; Shi, J.; Chen, H. A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy. Theranostics 2017, 7 (6), 1531-1542. DOI: 10.7150/thno.17247.

NLM
Mou J, Lin T, Huang F, Shi J, Chen H. A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy. Theranostics 2017; 7(6):1531-1542. doi:10.7150/thno.17247. https://www.thno.org/v07p1531.htm

CSE
Mou J, Lin T, Huang F, Shi J, Chen H. 2017. A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy. Theranostics. 7(6):1531-1542.

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