Theranostics 2017; 7(5):1245-1256. doi:10.7150/thno.18187

Research Paper

A Programmed Nanoparticle with Self-Adapting for Accurate Cancer Cell Eradication and Therapeutic Self-Reporting

Yingping Luo1, Liwei Huang1, Ye Yang1, Xianfei Zhuang1, Siyao Hu1, Huangxian Ju2, Bo-Yang Yu1✉, Jiangwei Tian1✉

1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 211198, P.R. China
2. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P.R. China

Abstract

To achieve the best therapeutic efficacy and good prognosis, the drugs necessitate tailored profiles of excellent spatiotemporal control and therapeutic monitoring. Here we introduce a programmed theranostic nanoparticle with self-adapting properties for tumor-specific systemic treatment, including stealthy surface to prolong circulation time in blood, surface charge-reversion for tumor targeting, receptor-mediated internalization to increase intracellular accumulation, “proton sponge effect” for controllable drug release and escape from endo/lysosome. Encouragingly, in the process of drug-induced apoptosis, the therapeutic efficacy can be reported by fluorescence imaging in vivo, in situ and in real time. Therefore, this work provides a new paradigm for design of programmed theranositc nanomedicine and offers promising prospects for precise tumor treatment.

Keywords: cancer, programmed nanoparticle, drug release, self-adapting, therapeutic self-reporting

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How to cite this article:
Luo Y, Huang L, Yang Y, Zhuang X, Hu S, Ju H, Yu BY, Tian J. A Programmed Nanoparticle with Self-Adapting for Accurate Cancer Cell Eradication and Therapeutic Self-Reporting. Theranostics 2017; 7(5):1245-1256. doi:10.7150/thno.18187. Available from http://www.thno.org/v07p1245.htm