Theranostics 2016; 6(9):1293-1305. doi:10.7150/thno.15081 This issue Cite

Research Paper

Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging

Yunkun Li#, Yachao Li#, Xiao Zhang, Xianghui Xu, Zhijun Zhang, Cheng Hu, Yiyan He, Zhongwei Gu

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, China.
#These authors contributed equally in this work.

Citation:
Li Y, Li Y, Zhang X, Xu X, Zhang Z, Hu C, He Y, Gu Z. Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging. Theranostics 2016; 6(9):1293-1305. doi:10.7150/thno.15081. https://www.thno.org/v06p1293.htm
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Abstract

Graphic abstract

Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications. We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared (NIR) tracking. With a refined molecular/supramolecular engineering, supramolecular dendritic systems were stabilized by bioreducible disulfide bonds and endowed with NIR fluorescence probes, and PEGylated platinum derivatives coordinated onto the abundant peripheral groups of supramolecular dendritic templates to generate pH/redox dual-responsive theranostic supramolecular PEGylated dendritic systems (TSPDSs). TSPDSs markedly improved the pharmacokinetics and biodistribution of platinum-based drugs, owing to their stable nanostructures and PEGylated shells during the blood circulation. Tumor intracellular environment (low pH value and high glutathione concentration) could trigger the rapid disintegration of TSPDSs due to acid-labile coordination bonds and redox-cleavable disulfide linkages, and then platinum-based drugs were delivered into the nuclei to exert antitumor activity. In vivo antitumor treatments indicated TSPDSs not only provided high antitumor efficiency which was comparable to clinical cisplatin, but also reduced renal toxicity of platinum-based drugs. Moreover, NIR fluorescence of TSPDSs successfully visualized in vitro and in vivo fate of nanoplatforms and disclosed the intracellular platinum delivery and pharmacokinetics. These results confirm tailor-made supramolecular dendritic system with sophisticated nanostructure and excellent performance is a promising candidate as smart theranostic nanoplatforms.

Keywords: supramolecular dendritic systems, theranostic nanoplatform, pH and redox sensitivity, platinum delivery, near-infrared imaging


Citation styles

APA
Li, Y., Li, Y., Zhang, X., Xu, X., Zhang, Z., Hu, C., He, Y., Gu, Z. (2016). Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging. Theranostics, 6(9), 1293-1305. https://doi.org/10.7150/thno.15081.

ACS
Li, Y.; Li, Y.; Zhang, X.; Xu, X.; Zhang, Z.; Hu, C.; He, Y.; Gu, Z. Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging. Theranostics 2016, 6 (9), 1293-1305. DOI: 10.7150/thno.15081.

NLM
Li Y, Li Y, Zhang X, Xu X, Zhang Z, Hu C, He Y, Gu Z. Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging. Theranostics 2016; 6(9):1293-1305. doi:10.7150/thno.15081. https://www.thno.org/v06p1293.htm

CSE
Li Y, Li Y, Zhang X, Xu X, Zhang Z, Hu C, He Y, Gu Z. 2016. Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging. Theranostics. 6(9):1293-1305.

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