Theranostics 2015; 5(10):1144-1153. doi:10.7150/thno.11754

Research Paper

Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy

Renfa Liu1, Lijia Jing1,3, Dong Peng 2, Yong Li 3, Jie Tian2, Zhifei Dai 1✉

1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;
2. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;
3. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.

Abstract

The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.

Keywords: Copper sulfide nanoparticles, Nanotheranostic agent, Photoacoustic imaging, Magnatic resonance imaging, Photothermal therapy.

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How to cite this article:
Liu R, Jing L, Peng D, Li Y, Tian J, Dai Z. Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy. Theranostics 2015; 5(10):1144-1153. doi:10.7150/thno.11754. Available from http://www.thno.org/v05p1144.htm