Nanoparticles for Radiation Therapy Enhancement: the Key Parameters

Retif, Paul; Pinel, Sophie; Toussaint, Magali; Frochot, Céline; Chouikrat, Rima; Bastogne, Thierry; Barberi-Heyob, Muriel

doi:10.7150/thno.11642

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Theranostics 2015; 5(9):1030-1044. doi:10.7150/thno.11642 This issue Cite

Review

Nanoparticles for Radiation Therapy Enhancement: the Key Parameters

Paul Retif^1,2,3, Sophie Pinel^2,3, Magali Toussaint^2,3, Céline Frochot^4,5,#, Rima Chouikrat^4,5, Thierry Bastogne^2,3,6,#, Muriel Barberi-Heyob^2,3,#,✉

1. CHR Metz-Thionville, Hôpital de Mercy, Service de radiothérapie, 1 allée du Château, Ars-Laquenexy, 57530, France;
2. Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France;
3. CNRS, CRAN, UMR 7039, Vandœuvre-lès-Nancy Cedex, 54506, France;
4. Université de Lorraine, LRGP, UMR 7274, 1 rue Grandville, Nancy, 54000, France;
5. CNRS, LRGP, UMR 7274, 1 rue Grandville, Nancy, 54000, France;
6. Université de Lorraine, INRIA-BIGS & CRAN, BP 70239, Vandœuvre-lès-Nancy Cedex, 54506, France.
^# CNRS, GdR 3049 Photomed, France.

Citation:

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M. Nanoparticles for Radiation Therapy Enhancement: the Key Parameters. Theranostics 2015; 5(9):1030-1044. doi:10.7150/thno.11642. https://www.thno.org/v05p1030.htm

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Abstract

This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

Keywords: Cancer, Nanoparticles, Radiation therapy, Radiobiology, Radiosensitization, Photodynamic therapy.

Citation styles

APA

Retif, P., Pinel, S., Toussaint, M., Frochot, C., Chouikrat, R., Bastogne, T., Barberi-Heyob, M. (2015). Nanoparticles for Radiation Therapy Enhancement: the Key Parameters. Theranostics, 5(9), 1030-1044. https://doi.org/10.7150/thno.11642.

ACS

Retif, P.; Pinel, S.; Toussaint, M.; Frochot, C.; Chouikrat, R.; Bastogne, T.; Barberi-Heyob, M. Nanoparticles for Radiation Therapy Enhancement: the Key Parameters. Theranostics 2015, 5 (9), 1030-1044. DOI: 10.7150/thno.11642.

NLM

CSE

Retif P, Pinel S, Toussaint M, Frochot C, Chouikrat R, Bastogne T, Barberi-Heyob M. 2015. Nanoparticles for Radiation Therapy Enhancement: the Key Parameters. Theranostics. 5(9):1030-1044.

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