Theranostics 2014; 4(10):1052-1061. doi:10.7150/thno.9727

Research Paper

Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis

Tala1*, Songbo Xie1*, Xiaodong Sun2*, Xiaoou Sun1, Jie Ran1, Linlin Zhang1, Dengwen Li1, Min Liu1, Gang Bao2✉, Jun Zhou1,2✉

1. State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
2. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
*These authors contributed equally to this work.

Abstract

Breast cancer is the most prevalent cancer in women worldwide with a high mortality rate, and the identification of new biomarkers and targets for this disease is greatly needed. Here we present evidence that microtubule-associated protein (MAP) 7 domain-containing protein 3 (Mdp3) is highly expressed in clinical samples and cell lines of breast cancer. The expression of Mdp3 correlates with clinicopathological parameters indicating breast cancer malignancy. In addition, Mdp3 promotes breast cancer cell proliferation and motility in vitro and stimulates breast cancer growth and metastasis in mice. Mechanistic studies reveal that γ-tubulin interacts with and recruits Mdp3 to the centrosome and that the centrosomal localization of Mdp3 is required for its activity to promote breast cancer cell proliferation and motility. These findings suggest a critical role for Mdp3 in the growth and metastasis of breast cancer and may have important implications for the management of this disease.

Keywords: breast cancer, cell proliferation, cell motility, growth, metastasis.

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How to cite this article:
Tala , Xie S, Sun X, Sun X, Ran J, Zhang L, Li D, Liu M, Bao G, Zhou J. Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis. Theranostics 2014; 4(10):1052-1061. doi:10.7150/thno.9727. Available from http://www.thno.org/v04p1052.htm