Theranostics 2013; 3(4):258-266. doi:10.7150/thno.5701 This issue Cite

Research Paper

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos

Kan Wang1, Jiebing Ma1, Meng He1, Guo Gao1, Hao Xu1, Jie Sang2, Yuxia Wang2, Baoquan Zhao2, Daxiang Cui1✉

1. Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China;
2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 47 Taping Road , Peking 100850, PR China.

Citation:
Wang K, Ma J, He M, Gao G, Xu H, Sang J, Wang Y, Zhao B, Cui D. Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos. Theranostics 2013; 3(4):258-266. doi:10.7150/thno.5701. https://www.thno.org/v03p0258.htm
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Abstract

This study reports the effects of upconversion nanoparticles (UCNPs) LaF3:Yb,Er on zebrafish, with the aim of investigating UCNPs toxicity. LaF3:Yb,Er were prepared by an oleic acid/ionic liquid two-phase system, and characterized by transmission electron microscope and X-ray powder diffraction. 140 zebrafish embryos were divided into six test groups and one control group, and respectively were injected into 5, 25, 50, 100, 200, 400 μg/mL LaF3:Yb,Er@SiO2 solution, and respectively were raised for 5 days. Each experiment was repeated ten times. Results showed that water-soluble LaF3:Yb,Er were successfully prepared, and did not exhibit obvious toxicity to zebrafish embryos under 100 μg/mL, but exhibited chronic toxicities 200 μg/mL in vivo, resulting in malformations and delayed hatching rate and embryonic and larval development. The excretion channels of LaF3:Yb,Er in adult zebrafish were mainly found in the intestine after being injected evenly for 24 h. In conclusion, the exploration of LaF3:Yb,Er for in vivo applications in animals and humans must consider UCNPs biocompatibility.

Keywords: Upconversion nanoparticles (UCNPs), biocompatibility, toxicity, zebrafish embryo.


Citation styles

APA
Wang, K., Ma, J., He, M., Gao, G., Xu, H., Sang, J., Wang, Y., Zhao, B., Cui, D. (2013). Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos. Theranostics, 3(4), 258-266. https://doi.org/10.7150/thno.5701.

ACS
Wang, K.; Ma, J.; He, M.; Gao, G.; Xu, H.; Sang, J.; Wang, Y.; Zhao, B.; Cui, D. Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos. Theranostics 2013, 3 (4), 258-266. DOI: 10.7150/thno.5701.

NLM
Wang K, Ma J, He M, Gao G, Xu H, Sang J, Wang Y, Zhao B, Cui D. Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos. Theranostics 2013; 3(4):258-266. doi:10.7150/thno.5701. https://www.thno.org/v03p0258.htm

CSE
Wang K, Ma J, He M, Gao G, Xu H, Sang J, Wang Y, Zhao B, Cui D. 2013. Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos. Theranostics. 3(4):258-266.

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