Theranostics 2013; 3(3):167-180. doi:10.7150/thno.5716

Review

Analytical and Theranostic Applications of Gold Nanoparticles and Multifunctional Nanocomposites

Nikolai Khlebtsov1,2,✉, Vladimir Bogatyrev1,2, Lev Dykman1, Boris Khlebtsov1, Sergey Staroverov1, Alexander Shirokov1, Larisa Matora1, Vitaly Khanadeev1, Timofey Pylaev1, Natalia Tsyganova3, Georgy Terentyuk2,3

1. Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS), Russian Federation;
2. Saratov State University, Russian Federation;
3. Ulyanovsk State University, Russian Federation.

Abstract

Gold nanoparticles (GNPs) and GNP-based multifunctional nanocomposites are the subject of intensive studies and biomedical applications. This minireview summarizes our recent efforts in analytical and theranostic applications of engineered GNPs and nanocomposites by using plasmonic properties of GNPs and various optical techniques. Specifically, we consider analytical biosensing; visualization and bioimaging of bacterial, mammalian, and plant cells; photodynamic treatment of pathogenic bacteria; and photothermal therapy of xenografted tumors. In addition to recently published reports, we discuss new data on dot immunoassay diagnostics of mycobacteria, multiplexed immunoelectron microscopy analysis of Azospirillum brasilense, materno-embryonic transfer of GNPs in pregnant rats, and combined photodynamic and photothermal treatment of rat xenografted tumors with gold nanorods covered by a mesoporous silica shell doped with hematoporphyrin.

Keywords: Gold nanoparticles, multifunctional nanocomposites, immunoassay, DNA detection, cell bioimaging, mycobacteria, Azospirillum brasilense, photodynamic and photothermal therapy, placental barrier, materno-embryonic transfer of gold nanoparticles.

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How to cite this article:
Khlebtsov N, Bogatyrev V, Dykman L, Khlebtsov B, Staroverov S, Shirokov A, Matora L, Khanadeev V, Pylaev T, Tsyganova N, Terentyuk G. Analytical and Theranostic Applications of Gold Nanoparticles and Multifunctional Nanocomposites. Theranostics 2013; 3(3):167-180. doi:10.7150/thno.5716. Available from http://www.thno.org/v03p0167.htm