Theranostics
2012; 2(6):541-552.
doi:10.7150/thno.3682 This issueCite
Review
Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview
Teresa Simón-Yarza1, Fabio R. Formiga1, Esther Tamayo1, Beatriz Pelacho2, Felipe Prosper2✉, María J. Blanco-Prieto1✉
1. Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, University of Navarra, Pamplona, Spain; 2. Hematology Service and Area of Cell Therapy, Clínica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain.
✉ Corresponding author: Maria J. Blanco-Prieto, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Irunlarrea 1, E-31080 Pamplona, Spain. Tel.: +34 948 425600 x 6519; fax: +34 948 425649 e-mail: mjblancoes, and Felipe Prosper, Hematology and Cell Therapy, Clínica Universidad de Navarra, Av. Pío XII 36, Pamplona 31008, Spain. Phone +34 948 255400 Fax +34 948 296500. E-mail: fprosperes
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Citation:
Simón-Yarza T, Formiga FR, Tamayo E, Pelacho B, Prosper F, Blanco-Prieto MJ. Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview. Theranostics 2012; 2(6):541-552. doi:10.7150/thno.3682. https://www.thno.org/v02p0541.htm
Since the discovery of the Vascular Endothelial Growth Factor (VEGF) and its leading role in the angiogenic process, this has been seen as a promising molecule for promoting neovascularization in the infarcted heart. However, even though several clinical trials were initiated, no therapeutic effects were observed, due in part to the short half life of this factor when administered directly to the tissue. In this context, drug delivery systems appear to offer a promising strategy to overcome limitations in clinical trials of VEGF.
The aim of this paper is to review the principal drug delivery systems that have been developed to administer VEGF in cardiovascular disease. Studies published in the last 5 years are reviewed and the main features of these systems are explained. The tissue engineering concept is introduced as a therapeutic alternative that holds promise for the near future.
Keywords: VEGF, protein delivery, cardiovascular disease, angiogenesis, tissue engineering.
Citation styles
APA
Simón-Yarza, T., Formiga, F.R., Tamayo, E., Pelacho, B., Prosper, F., Blanco-Prieto, M.J. (2012). Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview. Theranostics, 2(6), 541-552. https://doi.org/10.7150/thno.3682.
ACS
Simón-Yarza, T.; Formiga, F.R.; Tamayo, E.; Pelacho, B.; Prosper, F.; Blanco-Prieto, M.J. Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview. Theranostics 2012, 2 (6), 541-552. DOI: 10.7150/thno.3682.
NLM
Simón-Yarza T, Formiga FR, Tamayo E, Pelacho B, Prosper F, Blanco-Prieto MJ. Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview. Theranostics 2012; 2(6):541-552. doi:10.7150/thno.3682. https://www.thno.org/v02p0541.htm
CSE
Simón-Yarza T, Formiga FR, Tamayo E, Pelacho B, Prosper F, Blanco-Prieto MJ. 2012. Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview. Theranostics. 2(6):541-552.