Theranostics 2012; 2(4):403-412. doi:10.7150/thno.3634

Review

Magnetic Resonance Reporter Gene Imaging

Sheen-Woo Lee1✉, Sang-Hoon Lee2, Sandip Biswal3

1. Department of Radiology, Gil Hospital, Gachon University School of Medicine and Science, Inchon, Republic of Korea
2. Department of Radiology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Republic of Korea
3. Department of Radiology, Stanford University School of Medicine, Stanford, United States

Abstract

Molecular imaging has undergone an explosive advancement in recent years, due to the tremendous research efforts made to understand and visualize biological processes. Molecular imaging by definition assesses cellular and molecular processes in living subjects, with the targets of following metabolic, genomic, and proteomic events. Furthermore, reporter gene imaging plays a central role in this field. Many different approaches have been used to visualize genetic events in living subjects, such as, optical, radionuclide, and magnetic resonance imaging. Compared with the other techniques, magnetic resonance (MR)-based reporter gene imaging has not occupied center stage, despite its superior three-dimensional depictions of anatomical details. In this article, the authors review the principles and applications of various types of MR reporter gene imaging technologies and discuss their advantages and disadvantages.

Keywords: Magnetic resonance imaging, Reporter gene, molecular imaging.

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How to cite this article:
Lee SW, Lee SH, Biswal S. Magnetic Resonance Reporter Gene Imaging. Theranostics 2012; 2(4):403-412. doi:10.7150/thno.3634. Available from http://www.thno.org/v02p0403.htm