Theranostics 2012; 2(2):148-155. doi:10.7150/thno.4077

Review

Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival

Howard H. Chen1,2, Hushan Yuan3, Lee Josephson1,3, David E. Sosnovik1,2✉

1. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA
2. Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston MA
3. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA

Abstract

Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These include PI3-kinase, AKT and caspase-3. Here we review the approaches used to date to perform molecular imaging of these important targets. We focus in particular on approaches that include the possibility of modulating the activity of these kinases and proteases in a theranostic approach.

Keywords: Molecular Imaging, Theranostic, Cell Death, Apoptosis, PI3K

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How to cite this article:
Chen HH, Yuan H, Josephson L, Sosnovik DE. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics 2012; 2(2):148-155. doi:10.7150/thno.4077. Available from http://www.thno.org/v02p0148.htm