Graphic abstract

Review Micro/nanorobotics for sepsis diagnosis and therapy: a frontier in precision medicine Yukun Liu, Kang Wang, Guoyun Wan, Fangli Gao, Huiming Tang, Xiangjun Bai, Zhanfei Li, Yuchang Wang Theranostics 2026; 16(15): 8757-8774. doi:10.7150/thno.139332 Full text PDF


Graphic abstract

Research Paper PEGylated IL2 and tumor-targeted radiotherapy augment CD8+ T cell-mediated anti-tumor response to anti-PD-1 in head and neck squamous cell carcinoma Won Jong Jin, Hari Menon, Amber Bates, Lauren Zebertavage, Yujuan Wang, Paul A. Clark, Alexander A. Pieper, Caroline P. Kerr, Tracy J. Berg, Jens C Eickhoff, Sarah Seiter, A Mario Q. Marcondes, Mary A. Tagliaferri, Willem W. Overwijk, Tabassum A. Kennedy, Paul M. Sondel, Paul M. Harari, Justine Y. Bruce, Adam R. Burr, Reinier Hernandez, Irene M Ong, Jamey Weichert, Zachary S. Morris Theranostics 2026; 16(15): 8733-8756. doi:10.7150/thno.135255 Full text PDF


Graphic abstract

Research Paper Targeting USP22 reprograms the tumor microenvironment and sensitizes KRAS/p53-driven lung cancer to anti-PD-1 immunotherapy Keqiang Zhang, Ching Ouyang, Jonathan Castillo, Jinhui Wang, Walter Tsark, Yuanyuan Gao, Wendong Li, Minxiao Yang, Aimin Li, Britney Oeung, Colt Egelston, Jun Wu, Mahima Raul, Leonidas Arvanitis, Crystal Marconett, Dan J Raz Theranostics 2026; 16(15): 8708-8732. doi:10.7150/thno.125898 Full text PDF


Graphic abstract

Research Paper Cardiomyocyte-Specific RNF128 Attenuates Pathological Cardiac Hypertrophy Progression by Stabilizing SERCA2a through Lys63-Linked Polyubiquitination Yujie Zhang, Xuehan Liu, Liwen Yu, Changhao Liu, Jingwei Li, Qingmei Han, Xiaohong Wang, Lei Cao, Liangyu Cai, Linqi Jiao, Guohai Su, Meng Zhang, Cheng Zhang Theranostics 2026; 16(15): 8689-8707. doi:10.7150/thno.133221 Full text PDF


Graphic abstract

Research Paper Mapping endometrial vascular functional gradients using depth-derived ultrasound localization microscopy (D-ULM) for early stratification of postinjury fibrotic remodeling and therapeutic guidance Xiaowen Liang, Le Gao, Zhili Guo, Meng Du, Yue Pan, Yixiang Lian, Yu Qiang, Haijun Luo, Ying Zhang, Xiaoyan Kui, Hairong Zheng, Weibao Qiu, Zhiyi Chen Theranostics 2026; 16(15): 8669-8688. doi:10.7150/thno.138622 Full text PDF


Graphic abstract

Research Paper Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy Xin Chen, Yuhan Jiang, Weiqi Qian, Yi Lei, Siyue Chen, Yutian Zhang, Minghui Liang, Yuming Liu, Xiaohong Wang, Ding Ai, Xuyang Yao, Hua Yan Theranostics 2026; 16(15): 8650-8668. doi:10.7150/thno.136054 Full text PDF

More ...

Issue 13; 2026

Cover image

Founding Editor-in-Chief:
Prof. Xiaoyuan (Shawn) Chen, PhD
Profile


Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.



Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy

Ocular neovascular disease, characterized by aberrant angiogenesis in the eye, is a primary cause of global vision impairment and blindness. As the primary barrier exposed to hypoxia-related blood metabolites, endothelial cells (ECs) undergo metabolic reprogramming that drives pathological angiogenesis. However, the epigenetic mechanisms that link EC metabolic dysfunction to retinal vasculopathy remain elusive. Methods: Using western blotting and ...

Popup Image