Theranostics 2020; 10(15):6987-7001. doi:10.7150/thno.44569 This issue Cite

Research Paper

TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy

Yuanli Luo1*, Bin Qiao1*, Ping Zhang1, Chao Yang2, Jin Cao1, Xun Yuan3, Haitao Ran1, Zhigang Wang1, Lan Hao1, Yang Cao1, Jianli Ren1✉, Zhiyi Zhou4✉

1. Ultrasound Department of the Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, P. R. China.
2. Radiology Department of Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, P. R. China.
3. Ophthalmology Department of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
4. General Practice Department of Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, P. R. China.
*Yuanli Luo and Bin Qiao are co-first authors who contributed equally to this work.

Citation:
Luo Y, Qiao B, Zhang P, Yang C, Cao J, Yuan X, Ran H, Wang Z, Hao L, Cao Y, Ren J, Zhou Z. TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy. Theranostics 2020; 10(15):6987-7001. doi:10.7150/thno.44569. https://www.thno.org/v10p6987.htm
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Abstract

Graphic abstract

Adenosine triphosphate (ATP), as a key substance for regulating tumor progression in the tumor microenvironemnt (TME), is an emerging target for tumor theranostics. Herein, we report a minimalist but versatile nanoplatform with simultaneously TME-responsive drug release, TME-enhanced imaging, ATP-depletion sensitized chemotherapy and photothermal therapy for intelligent tumor theranostics.

Methods: The Fe3+ and tannic acid (TA) coordination were self-deposited on doxorubicin (Dox) in a facile method to prepare Dox-encapsulated nanoparticles (DFTNPs).

Results: When irradiated by a near infrared laser, the DFTNPs could elevate the temperature in the tumor region efficiently. Subsequently, the Dox could be released by the disassembly of Fe3+/TA in the TME to initiate chemotherapy. Particularly, the smart nanoagent not only enabled ATP-depletion and enhanced the therapeutic effect of chemotherapy, but also acted as photothermal transduction agent for photothermal therapy. Moreover, the nanoagent also acted as T1-weighted MR imaging,photoacoustic imaging and photothermal imaging contrast agent. The mice treated by DFTNPs plus laser showed a complete tumor eradication in 14d observation.

Conclusion: This as-prepared versatile nanoplatform offers new insights toward the application of smart nanoagents for improved tumor theranostics.

Keywords: adenosine triphosphate, responsive drug release, anti-tumor therapy, chemosensitivity, synergistic therapy, multimodal imaging


Citation styles

APA
Luo, Y., Qiao, B., Zhang, P., Yang, C., Cao, J., Yuan, X., Ran, H., Wang, Z., Hao, L., Cao, Y., Ren, J., Zhou, Z. (2020). TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy. Theranostics, 10(15), 6987-7001. https://doi.org/10.7150/thno.44569.

ACS
Luo, Y.; Qiao, B.; Zhang, P.; Yang, C.; Cao, J.; Yuan, X.; Ran, H.; Wang, Z.; Hao, L.; Cao, Y.; Ren, J.; Zhou, Z. TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy. Theranostics 2020, 10 (15), 6987-7001. DOI: 10.7150/thno.44569.

NLM
Luo Y, Qiao B, Zhang P, Yang C, Cao J, Yuan X, Ran H, Wang Z, Hao L, Cao Y, Ren J, Zhou Z. TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy. Theranostics 2020; 10(15):6987-7001. doi:10.7150/thno.44569. https://www.thno.org/v10p6987.htm

CSE
Luo Y, Qiao B, Zhang P, Yang C, Cao J, Yuan X, Ran H, Wang Z, Hao L, Cao Y, Ren J, Zhou Z. 2020. TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy. Theranostics. 10(15):6987-7001.

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