Theranostics 2020; 10(15):6987-7001. doi:10.7150/thno.44569 This issue Cite
Research Paper
1. Ultrasound Department of the Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, 400010, P. R. China.
2. Radiology Department of Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, P. R. China.
3. Ophthalmology Department of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.
4. General Practice Department of Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, P. R. China.
*Yuanli Luo and Bin Qiao are co-first authors who contributed equally to this work.
Adenosine triphosphate (ATP), as a key substance for regulating tumor progression in the tumor microenvironemnt (TME), is an emerging target for tumor theranostics. Herein, we report a minimalist but versatile nanoplatform with simultaneously TME-responsive drug release, TME-enhanced imaging, ATP-depletion sensitized chemotherapy and photothermal therapy for intelligent tumor theranostics.
Methods: The Fe3+ and tannic acid (TA) coordination were self-deposited on doxorubicin (Dox) in a facile method to prepare Dox-encapsulated nanoparticles (DFTNPs).
Results: When irradiated by a near infrared laser, the DFTNPs could elevate the temperature in the tumor region efficiently. Subsequently, the Dox could be released by the disassembly of Fe3+/TA in the TME to initiate chemotherapy. Particularly, the smart nanoagent not only enabled ATP-depletion and enhanced the therapeutic effect of chemotherapy, but also acted as photothermal transduction agent for photothermal therapy. Moreover, the nanoagent also acted as T1-weighted MR imaging,photoacoustic imaging and photothermal imaging contrast agent. The mice treated by DFTNPs plus laser showed a complete tumor eradication in 14d observation.
Conclusion: This as-prepared versatile nanoplatform offers new insights toward the application of smart nanoagents for improved tumor theranostics.
Keywords: adenosine triphosphate, responsive drug release, anti-tumor therapy, chemosensitivity, synergistic therapy, multimodal imaging