Theranostics 2020; 10(7):2965-2981. doi:10.7150/thno.40858 This issue Cite

Review

Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications

Prashant Chandrasekharan1✉, Zhi Wei Tay1, Daniel Hensley2, Xinyi Y Zhou1, Barry KL Fung1, Caylin Colson1, Yao Lu1, Benjamin D Fellows1, Quincy Huynh3, Chinmoy Saayujya3, Elaine Yu2, Ryan Orendorff2, Bo Zheng1, Patrick Goodwill2, Carlos Rinaldi4, Steven Conolly1,3

1. University of California Berkeley, Department of Bioengineering, Berkeley, CA 94720, United States
2. Magnetic Insight, Inc., Alameda, CA 94501, United States
3. Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, United States
4. University of Florida, J. Crayton Pruitt Family Department of Biomedical Engineering and Department of Chemical Engineering, FL, 32611 United States

Citation:
Chandrasekharan P, Tay ZW, Hensley D, Zhou XY, Fung BKL, Colson C, Lu Y, Fellows BD, Huynh Q, Saayujya C, Yu E, Orendorff R, Zheng B, Goodwill P, Rinaldi C, Conolly S. Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications. Theranostics 2020; 10(7):2965-2981. doi:10.7150/thno.40858. https://www.thno.org/v10p2965.htm
Other styles

File import instruction

Abstract

Graphic abstract

Magnetic fluid hyperthermia (MFH) treatment makes use of a suspension of superparamagnetic iron oxide nanoparticles, administered systemically or locally, in combination with an externally applied alternating magnetic field, to ablate target tissue by generating heat through a process called induction. The heat generated above the mammalian euthermic temperature of 37°C induces apoptotic cell death and/or enhances the susceptibility of the target tissue to other therapies such as radiation and chemotherapy. While most hyperthermia techniques currently in development are targeted towards cancer treatment, hyperthermia is also used to treat restenosis, to remove plaques, to ablate nerves and to alleviate pain by increasing regional blood flow. While RF hyperthermia can be directed invasively towards the site of treatment, non-invasive localization of heat through induction is challenging. In this review, we discuss recent progress in the field of RF magnetic fluid hyperthermia and introduce a new diagnostic imaging modality called magnetic particle imaging that allows for a focused theranostic approach encompassing treatment planning, treatment monitoring and spatially localized inductive heating.

Keywords: Theranostics, RF hyperthermia, RF treatment planning, RF treatment monitoring, magnetic fluid hyperthermia, hyperthermia, Magnetic Particle Imaging, Magnetic Nanoparticles, Superparamagnetic Iron Oxide Nanoparticles, in vivo Tracking


Citation styles

APA
Chandrasekharan, P., Tay, Z.W., Hensley, D., Zhou, X.Y., Fung, B.KL., Colson, C., Lu, Y., Fellows, B.D., Huynh, Q., Saayujya, C., Yu, E., Orendorff, R., Zheng, B., Goodwill, P., Rinaldi, C., Conolly, S. (2020). Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications. Theranostics, 10(7), 2965-2981. https://doi.org/10.7150/thno.40858.

ACS
Chandrasekharan, P.; Tay, Z.W.; Hensley, D.; Zhou, X.Y.; Fung, B.KL.; Colson, C.; Lu, Y.; Fellows, B.D.; Huynh, Q.; Saayujya, C.; Yu, E.; Orendorff, R.; Zheng, B.; Goodwill, P.; Rinaldi, C.; Conolly, S. Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications. Theranostics 2020, 10 (7), 2965-2981. DOI: 10.7150/thno.40858.

NLM
Chandrasekharan P, Tay ZW, Hensley D, Zhou XY, Fung BKL, Colson C, Lu Y, Fellows BD, Huynh Q, Saayujya C, Yu E, Orendorff R, Zheng B, Goodwill P, Rinaldi C, Conolly S. Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications. Theranostics 2020; 10(7):2965-2981. doi:10.7150/thno.40858. https://www.thno.org/v10p2965.htm

CSE
Chandrasekharan P, Tay ZW, Hensley D, Zhou XY, Fung BKL, Colson C, Lu Y, Fellows BD, Huynh Q, Saayujya C, Yu E, Orendorff R, Zheng B, Goodwill P, Rinaldi C, Conolly S. 2020. Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications. Theranostics. 10(7):2965-2981.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image