Theranostics 2014; 4(12):1176-1192. doi:10.7150/thno.8715 This issue Cite

Review

MicroRNAs Associated With HBV Infection And HBV-related HCC

Kun-Lin Xie1, Yan-Ge Zhang2, Jun Liu3, Yong Zeng1, Hong Wu1✉

1. The Department of Liver Surgery & Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China;
2. The Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China;
3. The Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, China.

Citation:
Xie KL, Zhang YG, Liu J, Zeng Y, Wu H. MicroRNAs Associated With HBV Infection And HBV-related HCC. Theranostics 2014; 4(12):1176-1192. doi:10.7150/thno.8715. https://www.thno.org/v04p1176.htm
Other styles

File import instruction

Abstract

Hepatitis B virus (HBV) infection is a global problem and a major risk factor for hepatocellular carcinoma (HCC). microRNAs (miRNAs) comprise a group of small noncoding RNAs regulating gene expression at the posttranslational level, thereby participating in fundamental biological processes, including cell proliferation, differentiation, and apoptosis. In this review, we summarize the roles of miRNAs in HBV infection, the recently identified mechanism underlying dysregulation of miRNAs in HBV-associated HCC, and their association with hepatocarcinogenesis. Moreover, we discuss the recent advances in the use of circulating miRNAs in the early diagnosis of HCC as well as therapies based on these aberrantly expressed miRNAs.

Keywords: MicroRNA, Hepatitis B virus, Hepatocellular carcinoma, Diagnosis, Therapy.


Citation styles

APA
Xie, K.L., Zhang, Y.G., Liu, J., Zeng, Y., Wu, H. (2014). MicroRNAs Associated With HBV Infection And HBV-related HCC. Theranostics, 4(12), 1176-1192. https://doi.org/10.7150/thno.8715.

ACS
Xie, K.L.; Zhang, Y.G.; Liu, J.; Zeng, Y.; Wu, H. MicroRNAs Associated With HBV Infection And HBV-related HCC. Theranostics 2014, 4 (12), 1176-1192. DOI: 10.7150/thno.8715.

NLM
Xie KL, Zhang YG, Liu J, Zeng Y, Wu H. MicroRNAs Associated With HBV Infection And HBV-related HCC. Theranostics 2014; 4(12):1176-1192. doi:10.7150/thno.8715. https://www.thno.org/v04p1176.htm

CSE
Xie KL, Zhang YG, Liu J, Zeng Y, Wu H. 2014. MicroRNAs Associated With HBV Infection And HBV-related HCC. Theranostics. 4(12):1176-1192.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image