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Volume 9 (4); 2019

Research Papers

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Serum miR-626 and miR-5100 are Promising Prognosis Predictors for Oral Squamous Cell Carcinoma
Jianbo Shi, Xin Bao, Zengying Liu, Zhiyuan Zhang, Wantao Chen, Qin Xu
Theranostics 2019; 9(4): 920-931. doi:10.7150/thno.30339
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Quantitative MALDI Imaging of Spatial Distributions and Dynamic Changes of Tetrandrine in Multiple Organs of Rats
Weiwei Tang, Jun Chen, Jie Zhou, Junyue Ge, Ying Zhang, Ping Li, Bin Li
Theranostics 2019; 9(4): 932-944. doi:10.7150/thno.30408
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways
Meng Ma, Jie Dai, Huan Tang, Tianxiao Xu, Sifan Yu, Lu Si, Chuanliang Cui, Xinan Sheng, Zhihong Chi, Lili Mao, Xiaowen Wu, Lu Yang, Huan Yu, Siming Li, Bin Lian, Bixiang Tang, Xuan Wang, Xieqiao Yan, Xue Bai, Li Zhou, Yan Kong, Jun Guo
Theranostics 2019; 9(4): 945-960. doi:10.7150/thno.30516
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Silk Fibroin-Coated Nanoagents for Acidic Lysosome Targeting by a Functional Preservation Strategy in Cancer Chemotherapy
Mixiao Tan, Weiwei Liu, Fengqiu Liu, Wei Zhang, Hui Gao, Juan Cheng, Yu Chen, Zhigang Wang, Yang Cao, Haitao Ran
Theranostics 2019; 9(4): 961-973. doi:10.7150/thno.30765
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Near infrared imaging of epidermal growth factor receptor positive xenografts in mice with domain I/II specific antibody fragments
Wendy Bernhard, Ayman El-Sayed, Kris Barreto, Carolina Gonzalez, Humphrey Fonge, Clarence Ronald Geyer
Theranostics 2019; 9(4): 974-985. doi:10.7150/thno.30835
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN
Qitong Zhang, Qingquan Zhang, Xue Jiang, Youqiong Ye, Huimin Liao, Fugui Zhu, Jie Yan, Lina Luo, Li Tian, Cizhong Jiang, Yihan Chen, Xingqun Liang, Yunfu Sun
Theranostics 2019; 9(4): 986-1000. doi:10.7150/thno.30199
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor-secreted dickkopf2 accelerates aerobic glycolysis and promotes angiogenesis in colorectal cancer
Fengliu Deng, Rui Zhou, Chuang Lin, Shibin Yang, Hui Wang, Weidong Li, Kehong Zheng, Wandie Lin, Xin Li, Xueqing Yao, Mingxin Pan, Liang Zhao
Theranostics 2019; 9(4): 1001-1014. doi:10.7150/thno.30056
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Human parthenogenetic neural stem cell grafts promote multiple regenerative processes in a traumatic brain injury model
Jea-Young Lee, Sandra Acosta, Julian P. Tuazon, Kaya Xu, Hung Nguyen, Trenton Lippert, Michael G. Liska, Andrey Semechkin, Ibon Garitaonandia, Rodolfo Gonzalez, Russell Kern, Cesario V. Borlongan
Theranostics 2019; 9(4): 1029-1046. doi:10.7150/thno.29868
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer
Hui Huang, Yang Dong, Yanhua Zhang, Dan Ru, Zhihua Wu, Jiali Zhang, Ming Shen, Yourong Duan, Ying Sun
Theranostics 2019; 9(4): 1047-1065. doi:10.7150/thno.29820
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nrf2 signaling and inflammation are key events in physical plasma-spurred wound healing
Anke Schmidt, Thomas von Woedtke, Brigitte Vollmar, Sybille Hasse, Sander Bekeschus
Theranostics 2019; 9(4): 1066-1084. doi:10.7150/thno.29754
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Zwitterionic near-infrared fluorophore-conjugated epidermal growth factor for fast, real-time, and target-cell-specific cancer imaging
Hyunjin Kim, Mi Hyeon Cho, Hak Soo Choi, Byung Il Lee, Yongdoo Choi
Theranostics 2019; 9(4): 1085-1095. doi:10.7150/thno.29719
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy
Xiaofei Zhang, Zihao Qi, Huijing Yin, Gong Yang
Theranostics 2019; 9(4): 1096-1114. doi:10.7150/thno.29673
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Genome-wide profiling of Epstein-Barr virus integration by targeted sequencing in Epstein-Barr virus associated malignancies
Miao Xu, Wei-Long Zhang, Qing Zhu, You-yuan Yao, Qi-Sheng Feng, Zhe Zhang, Rou-Jun Peng, Wei-Hua Jia, Gui-Ping He, Lin Feng, Zhao-Lei Zeng, Bing Luo, Rui-Hua Xu, Mu-Sheng Zeng, Wei-Li Zhao, Sai-Juan Chen, Yi-Xin Zeng, Yuchen Jiao
Theranostics 2019; 9(4): 1115-1124. doi:10.7150/thno.29622
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Microporous polysaccharide multilayer coated BCP composite scaffolds with immobilised calcitriol promote osteoporotic bone regeneration both in vitro and in vivo
Qian Tang, Zhichao Hu, Haiming Jin, Gang Zheng, XingFang Yu, Gang Wu, Haixiao Liu, Zhenzhong Zhu, Huazi Xu, Changqing Zhang, Liyan Shen
Theranostics 2019; 9(4): 1125-1143. doi:10.7150/thno.29566
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Synthesis of enantiopure 18F-trifluoromethyl cysteine as a structure-mimetic amino acid tracer for glioma imaging
Shaoyu Liu, Hui Ma, Zhanwen Zhang, Liping Lin, Gongjun Yuan, Xiaolan Tang, Dahong Nie, Shende Jiang, Guang Yang, Ganghua Tang
Theranostics 2019; 9(4): 1144-1153. doi:10.7150/thno.29405
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases
May Lin Yap, James D McFadyen, Xiaowei Wang, Melanie Ziegler, Yung-Chih Chen, Abbey Willcox, Cameron J Nowell, Andrew M Scott, Erica K Sloan, P Mark Hogarth, Geoffrey A Pietersz, Karlheinz Peter
Theranostics 2019; 9(4): 1154-1169. doi:10.7150/thno.29146
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration
Jiancheng Huang, Shun Gu, Meng Chen, Shu-jie Zhang, Zhichun Jiang, Xue Chen, Chao Jiang, Guohua Liu, Roxana A Radu, Xiantao Sun, Douglas Vollrath, Jianhai Du, Biao Yan, Chen Zhao
Theranostics 2019; 9(4): 1170-1180. doi:10.7150/thno.26281
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5
Sandy Giuliano, Maeva Dufies, Papa Diogop Ndiaye, Julien Viotti, Delphine Borchiellini, Julien Parola, Valérie Vial, Yann Cormerais, Mickaël Ohanna, Véronique Imbert, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Ariel Savina, Jean-Marc Ferrero, Baharia Mograbi, Gilles Pagès
Theranostics 2019; 9(4): 1181-1199. doi:10.7150/thno.29093
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Circulating proteomic panels for diagnosis and risk stratification of acute-on-chronic liver failure in patients with viral hepatitis B
Zeyu Sun, Xiaoli Liu, Daxian Wu, Hainv Gao, Jing Jiang, Ying Yang, Jie Wu, Qikang Gao, Jie Wang, Zhengyi Jiang, Youping Xu, Xiao Xu, Lanjuan Li
Theranostics 2019; 9(4): 1200-1214. doi:10.7150/thno.31991
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Design strategies and application progress of therapeutic exosomes
Chunying Liu, Changqing Su
Theranostics 2019; 9(4): 1015-1028. doi:10.7150/thno.30853
[Abstract] [Full text] [PDF] [PubMed] [PMC]