Theranostics 2019; 9(17):5035-5048. doi:10.7150/thno.35418 This issue Cite

Research Paper

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Tao Zheng1, Wentao Wang2, Fan Wu2, Ming Zhang1,2✉, Jian Shen2✉, Yi Sun1✉

1. Department of Health Technology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark;
2. Jiangsu Collaborative Innovation Center for Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.

Citation:
Zheng T, Wang W, Wu F, Zhang M, Shen J, Sun Y. Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy. Theranostics 2019; 9(17):5035-5048. doi:10.7150/thno.35418. https://www.thno.org/v09p5035.htm
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Abstract

Graphic abstract

With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO2 core-shell nanoparticles, which showed that they could selectively target and efficiently eliminate cancer cells via photothermal therapy (PTT), photodynamic therapy (PDT), pH/NIR-induced drug release, and cationic therapy.

Methods: In the present study, the multifunctional therapeutic agent [Mn@P(CitAPDMAEMA)@Au@TiO2@DOX] was prepared to treat cancer with imaging-guided combination method. Firstly, Au@TiO2 core-shell nanoparticles (NPs) were synthesized. Taking advantage of broad and strong photoabsorption and reactive oxygen species (ROS) generation, Au@TiO2 core-shell NPs facilitated the single light-induced PTT and PDT. Next, a chemotherapy drug doxorubicin (DOX) was loaded into Au@TiO2 core-shell NPs. Then, a biocompatible zwitterionic polymer P(CitAPDMAEMA) was grafted to improve the hemocompatibility of NPs and prolong the circulation time. The polymer also served as a capping or switching material for pH-triggered drug release. In addition, the cationic nature of P(CitAPDMAEMA) eased the binding to human cervical cancer (HeLa) cells and effectively inhibited their growth in acidic environments (termed cationic therapy). Moreover, with Mn2+ ions immanently chelated, Mn@P(CitAPDMAEMA)@Au@TiO2@DOX NPs were able to provide enhanced contrast under T1- or T2-weighted magnetic resonance imaging (MRI).

Results: The in vitro and in vivo anticancer experiments demonstrated the tumor was effectively inhibited with minimal side effects by the multifunctional NPs.

Conclusions: As far as we know, this is the first presentation of four therapeutic methods into one nanomaterial, which will open up a new dimension for the design of combined treatment.

Keywords: Au@TiO2 core-shell NPs, photothermal, photodynamic, cationic therapy, chemotherapy, magnetic resonance imaging


Citation styles

APA
Zheng, T., Wang, W., Wu, F., Zhang, M., Shen, J., Sun, Y. (2019). Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy. Theranostics, 9(17), 5035-5048. https://doi.org/10.7150/thno.35418.

ACS
Zheng, T.; Wang, W.; Wu, F.; Zhang, M.; Shen, J.; Sun, Y. Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy. Theranostics 2019, 9 (17), 5035-5048. DOI: 10.7150/thno.35418.

NLM
Zheng T, Wang W, Wu F, Zhang M, Shen J, Sun Y. Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy. Theranostics 2019; 9(17):5035-5048. doi:10.7150/thno.35418. https://www.thno.org/v09p5035.htm

CSE
Zheng T, Wang W, Wu F, Zhang M, Shen J, Sun Y. 2019. Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy. Theranostics. 9(17):5035-5048.

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