Theranostics 2018; 8(10):2709-2721. doi:10.7150/thno.20576

Review

Role of Extracellular Vesicles in Viral and Bacterial Infections: Pathogenesis, Diagnostics, and Therapeutics

Meryl Rodrigues1,2, Jia Fan1, Christopher Lyon1, Meihua Wan3✉, Ye Hu1,2✉

1. Virginia G. Piper Biodesign Center for Personalized Diagnostics, Arizona State University Biodesign Institute, Tempe, Arizona, 85287
2. School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, 85287
3. Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 610041

Abstract

Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules during infections to alter immune responses and pathophysiological processes. New research is beginning to decipher how EVs influence viral and bacterial pathogenesis. In this review, we will describe how EVs influence viral and bacterial pathogenesis by spreading pathogen-derived factors and how they can promote and inhibit the immune response to these pathogens. We will also discuss the emerging potential of EVs as diagnostic and therapeutic tools.

Keywords: extracellular vesicles, exosomes, pathogenesis, immune system, diagnostic, therapeutic

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How to cite this article:
Rodrigues M, Fan J, Lyon C, Wan M, Hu Y. Role of Extracellular Vesicles in Viral and Bacterial Infections: Pathogenesis, Diagnostics, and Therapeutics. Theranostics 2018; 8(10):2709-2721. doi:10.7150/thno.20576. Available from http://www.thno.org/v08p2709.htm