Theranostics 2017; 7(6):1407-1421. doi:10.7150/thno.18262 This issue Cite

Research Paper

Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs

Jiaqi Wang1*, Huamao Ye1*, Dandan Zhang1*, Kai Cheng1*, Yijun Hu1, Xiya Yu1, Lei Lu1, Jingjing Hu1, Changjing Zuo1, Baohua Qian1, Yongwei Yu1, Shupeng Liu1, Geng Liu2, Chuanbin Mao3, 4✉, Shanrong Liu1✉

1. Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, Nanjing 210061 China;
3. Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019-5300, USA;
4. School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
* These authors contributed equally to this work.

Citation:
Wang J, Ye H, Zhang D, Cheng K, Hu Y, Yu X, Lu L, Hu J, Zuo C, Qian B, Yu Y, Liu S, Liu G, Mao C, Liu S. Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs. Theranostics 2017; 7(6):1407-1421. doi:10.7150/thno.18262. https://www.thno.org/v07p1407.htm
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Abstract

Graphic abstract

Understanding the interaction between cancer cells and immunocytes will inspire new cancer therapy strategies. However, how cancer-derived circulating miRNAs modulate such interaction remains unclear. Here we discovered that circulating miR-410-5p, secreted by prostate cancer cells, entered dendritic cells (DCs), with the aid of argonaute-2 protein. The cancer cell antigens stimulated the DCs to produce miR-410-3p, a highly complementary counterpart of miR-410-5p derived from pre-miR-410. The DC-internalized miR-410-5p degraded the miR-410-3p by base pairing and thus inhibited its function in suppressing tumor angiogenesis, promoting tumor growth. Furthermore, blockade of the miR-410-5p upregulated the miR-410-3p to inhibit tumor growth. Our work suggests a new miRNA-mediated role of immunocytes in cancer progression and a new strategy of cancer therapy through suppressing circulating miRNAs.

Keywords: circulating microRNA, cancer angiogenesis, dendritic cells, prostate cancer.


Citation styles

APA
Wang, J., Ye, H., Zhang, D., Cheng, K., Hu, Y., Yu, X., Lu, L., Hu, J., Zuo, C., Qian, B., Yu, Y., Liu, S., Liu, G., Mao, C., Liu, S. (2017). Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs. Theranostics, 7(6), 1407-1421. https://doi.org/10.7150/thno.18262.

ACS
Wang, J.; Ye, H.; Zhang, D.; Cheng, K.; Hu, Y.; Yu, X.; Lu, L.; Hu, J.; Zuo, C.; Qian, B.; Yu, Y.; Liu, S.; Liu, G.; Mao, C.; Liu, S. Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs. Theranostics 2017, 7 (6), 1407-1421. DOI: 10.7150/thno.18262.

NLM
Wang J, Ye H, Zhang D, Cheng K, Hu Y, Yu X, Lu L, Hu J, Zuo C, Qian B, Yu Y, Liu S, Liu G, Mao C, Liu S. Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs. Theranostics 2017; 7(6):1407-1421. doi:10.7150/thno.18262. https://www.thno.org/v07p1407.htm

CSE
Wang J, Ye H, Zhang D, Cheng K, Hu Y, Yu X, Lu L, Hu J, Zuo C, Qian B, Yu Y, Liu S, Liu G, Mao C, Liu S. 2017. Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs. Theranostics. 7(6):1407-1421.

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