Theranostics 2013; 3(1):40-46. doi:10.7150/thno.5135 This issue Cite

Review

Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease

Lael Werner1, Hanan Guzner-Gur2, Iris Dotan1✉

1. IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
2. Department of Internal Medicine B, Tel Aviv Sourasky Medical Center affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Citation:
Werner L, Guzner-Gur H, Dotan I. Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease. Theranostics 2013; 3(1):40-46. doi:10.7150/thno.5135. https://www.thno.org/v03p0040.htm
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Abstract

Directional movement of cells in the human body is orchestrated via chemokines. This migration was initially identified in pathological and immunological processes but quickly extended to homeostatic cell trafficking. One such chemokine is the ubiquitous CXCL12 (initially called SDF1-α) which signals via the chemokine receptors CXCR4 and CXCR7. In the last decade CXCL12 was recognized to participate not only in embryonic development and homeostatic maintenance, but also in progression of inflammation. A role for CXCL12 and its receptors CXCR4 and CXCR7 in inflammatory bowel diseases was recently shown. The current review discusses up to date knowledge of CXCL12 in inflammation, focusing on the involvement of CXCL12 and its receptors, CXCR4 and CXCR7, in inflammatory bowel diseases.

Keywords: Chemokines. Inflammatory bowel disease. CXCL12. CXCR4. CXCR7.


Citation styles

APA
Werner, L., Guzner-Gur, H., Dotan, I. (2013). Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease. Theranostics, 3(1), 40-46. https://doi.org/10.7150/thno.5135.

ACS
Werner, L.; Guzner-Gur, H.; Dotan, I. Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease. Theranostics 2013, 3 (1), 40-46. DOI: 10.7150/thno.5135.

NLM
Werner L, Guzner-Gur H, Dotan I. Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease. Theranostics 2013; 3(1):40-46. doi:10.7150/thno.5135. https://www.thno.org/v03p0040.htm

CSE
Werner L, Guzner-Gur H, Dotan I. 2013. Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease. Theranostics. 3(1):40-46.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
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