Dissolvable microneedles loaded with denosumab alleviate knee osteoarthritis in rodent and canine models by inhibiting macrophage senescence
Chaochang Ming, Duohang Bi, Hongtao Tian, Weijian Liu, Haitao, Li, Yuxiang Hu, Zhenyu Song, Dongdong Xu, Hao Xu, Hongyan, Li, Shenghui Lan, Weihua, Xu, Chen Wei, Qiong Li, Jiawei, Feng, Qianqian, Cao, Xiaoyang Wang, Panlong Fan,Jintao Zhu, Wei Yu, Chaoge MingZhipeng Dai, Yijing Liu and Wei Tong, These authors contributed equally to the work, Corresponding authors
Theranostics 2025; doi:10.7150/thno.116970; accepted
Author manuscript

SOX9 and tumor microenvironment niche cooperatively promote transformation of gastric cancer stem cells and early tumorigenesis
Tiantian Du, Honglei Wu, Huiru Gao, Juan Li, Jie Gao, Yunshan Wang, Chuanxin Wang, Peilong Li, Lutao Du
Theranostics 2025; doi:10.7150/thno.116003; in press
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Enhancer-Mediated NR2F2 Recruitment Activates BGN to Promote Tumor Growth and Shape Tumor Microenvironment in Papillary Thyroid Cancer
Mei Tao, Xianhui Ruan, Jialong Yu, Qiman Dong, Wei Luo, Wei Zhang, Mengran Tian, Xiukun Hou, Linfei Hu, Jingzhu Zhao, Dapeng Li, Jie Hao, Songfeng Wei, Xiangqian Zheng, Ming Gao
Theranostics 2025; doi:10.7150/thno.113712; in press
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ROS-Targeting Heterojunction-Integrated GelMA Microneedles for Photo-Responsive Antioxidative Action and Accelerated Diabetic Wound Healing
Jinlan Tang, Weijun Liu, Zhengyao Zhang, Ye Yang, Wenwen Cheng, Xiaoyu Wang, Zesheng Chen, Zijian Wang, Weikang Hu
Theranostics 2025; doi:10.7150/thno.120879; in press
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Quantitatively controlled and measured-traumatic brain injury impairs adult neurogenesis and alters neuropathological signatures in mice
Sungwook Yang, Suhyun Kim, Uiyeol Park, Hyeonjoo Im, Hyesun Cho, Kyung Eun Lee, Junsang Yoo, Seung Jae Hyeon, Se Jeong Lee, Im Joo Rhyu, Junghee Lee, Ann C. McKee, Eui-Sung Yoon, Hoon Ryu
Theranostics 2025; doi:10.7150/thno.114693; accepted
Author manuscript

Advancements in CRISPR-Based Therapies for Ocular Pathologies: From Disease Mechanisms to Intervention Strategies
Qinghua Li, Qingdong Bao, Sihan Zhao, Fan Wu, Yang Li, Kaiyuan Wang, Wenlong Li, Hua Gao
Theranostics 2025; doi:10.7150/thno.117085; in press
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Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promotes the progression of PDAC
Shengnan Lv, Jian Zhang, Xinyu Peng, Huan Liu, Tongjia Chu, Ziyu Liu, Kehang Duan, Jianxiong guo, Jie Wang, Yan Liu, Feng Wei
Theranostics 2025; doi:10.7150/thno.117202; in press
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EZH2-mediated H3K27me3 links microbial inosine loss to depression: a gut-brain epigenetic switch
Sen Zhu, Xuan Li, Ying Yu, Xiaoyi Han, Fang Yang, Mengxi Lu, Gaole Dai, Liang Guo, Dan Xu
Theranostics 2025; doi:10.7150/thno.120824; in press
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Artesunate nanoliposome-hydrogel: a dual-modal therapy for post-surgical melanoma
Hongmei Chen, Zhongke Wang, Ying Huang, Aodi Li, Xinlei Xiong, Yifan Pu, Ling Guo
Theranostics 2025; doi:10.7150/thno.120793; accepted
Author manuscript

Kazald1 attenuates chondrocyte fibrosis to potentiate hyaline cartilage regeneration by interfering the pro-fibrotic TGF-β signaling
Yue Zhu, Haoyang Liu, Yuting Zhang, Danning Zheng, Yaning Li, Jialin Chen, Jiake Xu, Wei Zhang
Theranostics 2025; doi:10.7150/thno.113604; in press
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ASIC1a induces excessive mitophagy and PANoptosis of chondrocyte by the inhibition of SIRT3 mitochondrial translocation
Zhuoyan Zai, Xuewen Qian, Yayun Xu, Huifang Lv, Mengjia Hao, Yueming Tao, Lixin Rui, Xiaoyue Zhang, Xiaoqing Peng, Yihao Zhang, Feihu Chen
Theranostics 2025; doi:10.7150/thno.116712; in press
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Engineering a spleen-selective mRNA-LNPs vaccine by decoupling the inflammation from cellular immunity mediated cancer immunotherapy
Xiaoke Gao, Meng Zhang, Shiyang Du, Lixia Ma, Xiaohan Yao, Boao Xie, Jiajia Wan, Yuqiao Sheng, Bo Qin, Wenjing Deng, Ningjing Lei, Wentao Mo, Ming Wang, Zhijun Sun, Zhihai Qin, Fazhan Wang
Theranostics 2025; doi:10.7150/thno.118976; in press
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Single-shot multiparametric MRI for correcting T2-related bias in dynamic glucose-enhanced imaging
Junxian Jin, Haizhen Ding, Zhekai Chen, Yuan Huang, Hongmin Chen, Zhong Chen, Lin Chen
Theranostics 2025; doi:10.7150/thno.116483; in press
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Development of a potent and safe CD137 agonist
Kang Yi Lee, Heng Sun, Yu Mei, Emily Nickles, Clemence Wei Xia Lai, Sashigala Ponnalagu, Mukul Prasad, Xiaoyuan Chen, Haiyan Liu, Herbert Schwarz
Theranostics 2025; doi:10.7150/thno.116136; accepted
Author manuscript

Machine Learning-Enhanced Confocal Raman Imaging Enables Label-Free Diagnosis and Spatial Metabolic Profiling of Isoniazid-Induced Hepatotoxicity
Shimei Wang, Xiaoren Wang, Xudong Cui, Xiaotong Xie, Zhu Zhu, Tomii Ayaka, Renxing Song, Liping Zhou, Jin Sun, Li Zhang, Ruisheng Ge, Lei Yu, Yang Li
Theranostics 2025; doi:10.7150/thno.119785; in press
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GM-CSF+ Th: a central player in autoimmunity
Sha-Sha Fan, Xuan Xu, Yu-Bin Luo, Xiang-Yu Meng, Yi Liu
Theranostics 2025; doi:10.7150/thno.121766; in press
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Clathrin mediated endocytosis targeting chimera (CleTAC) for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy
Yishuang Li, Zhihong Zhou, Yonghui Lv, Haoneng Hu, Ming Chen, Kunjian Lei, Chuandong Gong, Junzhe Liu, Lufei Yang, Linzhen Huang, Wenji Liu, Jinying Li, Minhua Ye, Xingen Zhu, Kai Huang
Theranostics 2025; doi:10.7150/thno.114005; in press
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Cyclic Mechanical Stretching Enhances Mitophagy and Oxidative Stress Resistance in Adipose-Derived Stem Cells via the Piezo1/ATP Axis to Accelerate Wound Healing
Yujie Xiao, Zhijun Shi, Yixuan Yuan, Danna Yao, Rongqin Feng, Yue Zhang, Deli Zhao, Hao Zhang, Panpan Sun, Yang Liu, Yan Li, Xuefeng Shen, Zhantong Wang, Dahai Hu, Hao Guan, Hongtao Wang
Theranostics 2025; doi:10.7150/thno.118364; in press
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Luminal Stem-like Cells in High-risk/Locally Advanced Prostate Cancer Promote Resistance to Hormonal Therapy
Guyu Tang, Jing Liu, Xiaomei Gao, Kai Yuan, Minfeng Chen, Long Wang, Lin Qi, Yi Cai
Theranostics 2025; doi:10.7150/thno.112496; in press
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Naturally derived hydrogel with antioxidant, angiogenesis and photothermal effect to accelerate infected diabetic wound healing and reduce scar formation
Mengyu Yang, Pengyuan Liu, Pei Cheng, Chenghao Li, Jingmei Liu, Haifeng Sun, Fangxia Guan, Minghao Yao
Theranostics 2025; doi:10.7150/thno.117179; in press
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Integrative Spatially Resolved Proteomic and Metabolomic Imaging Reveals Synovitis Endotypes Implicated in Osteoarthritis Progression
Lin Zhu, Xin Diao, Chenrui Yuan, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen, Zongwei Cai
Theranostics 2025; doi:10.7150/thno.117788; in press
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The pathophysiology of mixed Alzheimer’s disease and vascular dementia
Mutaz Sarhan, Christian Wohlfeld, Ariel Perry-Mills, Jeffrey Meyers, James Fadel, E. Angela Murphy, Leonardo Bonilha, and Daping Fan
Theranostics 2025; doi:10.7150/thno.118737; in press
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Single-Cell RNA Sequencing Technology Revealed Endothelial Cell Heterogeneity and Sox18-mediated EndMT in Abdominal Aortic Aneurysm
Xianxian Wu, Xuanyu Liu, Yuanzhi Cheng, Yuhan Zhang, Dou Shi, Yang Shi, Xing Liu, Jianghao Feng, Anxiong Long, Wei Hu, Zhiwei Yang
Theranostics 2025; doi:10.7150/thno.110254; in press
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Dissecting Tertiary Lymphoid Structures in Cancer: Maturation, Localization, and Density
Guang-Liang Su, Meng-Jie Zhang, Hao Li, Zhi-Jun Sun
Theranostics 2025; doi:10.7150/thno.113940; in press
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Neutrophil-Based Delivery Platforms: From Natural Mechanisms to Engineered Therapeutics
Yinggang Li, Xue Zhang, Yunkun Li, Ling Sun, Na Hu, Su Lui, Zhenyu Duan, Qiyong Gong, Kui Luo
Theranostics 2025; doi:10.7150/thno.117363; in press
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Transcriptomic Profiling of the Tumor Immune Microenvironment Reveals Prognostic Markers in mCRPC Patients Treated with LuPSMA Therapy
Analena Handke, Leonor Lopes, Claudia Kesch, Christopher Darr, Elai Davicioni, Kuangyu Shi, Tugce Telli, Wolfgang P. Fendler, Ken Herrmann, Katharina Lückerath, Boris Hadaschik, Robert Seifert
Theranostics 2025; doi:10.7150/thno.113614; in press
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Super-Resolution Ultrasound Imaging of Vascular Dynamics to Monitor Focused Ultrasound Blood-Brain Barrier Opening
Sua Bae, Stephen A. Lee, Seongyeon Kim, Fotios Tsitsos, Yangpei Liu, and Elisa E. Konofagou
Theranostics 2025; doi:10.7150/thno.98098; accepted
Author manuscript

MR molecular imaging for monitoring and predicting tumor responses to immunotherapy in pancreatic cancer
Victoria E. A. Laney, Walter Zhao, Inga Hwang, Emma Hampson, Juan Dong, Ryan C. Hall, Kristin Weber-Bonk, Xueer Yuan, Elizabeth Delaney, Hannah Gilmore, Ruth Keri, Jordan Winter, Li Lily Wang and Zheng-Rong Lu
Theranostics 2025; doi:10.7150/thno.106481; accepted
Author manuscript